Barcelona will remain without goalkeeper Marc-André ter Stegen (back), Gavi (knee) and Dani Olmo (shoulder), with the injured trio still working their way back to fitness.
Ronald Araújo is on compassionate leave and was not expected to feature anyway due to the suspension he picked up against Chelsea. As a result, Gerard Martin may once again partner Pau Cubarsí at the heart of the defence, as seen against Betis.
Further forward, Raphinha could return to the XI after being named among the substitutes last time out, potentially pushing Marcus Rashford out of the side. However, the real dilemma for Hansi Flick lies in the centre-forward position. Ferran Torres excelled in the No. 9 role against Betis, raising the possibility that he may be preferred again ahead of veteran striker Robert Lewandowski, who remained on the bench for the entirety of that match.
Meanwhile, Frankfurt’s defeat to Leipzig came at a cost, with Michy Batshuayi forced off and ruled out of Tuesday’s clash.
The visitors already had concerns in attack, with top scorer Jonathan Burkardt sidelined after hobbling off against Atalanta, and he will also miss this encounter.
On the positive side, Can Uzun and Hugo Larsson both returned to the matchday squad in Leipzig following their respective injuries, meaning the key midfield duo could be involved here.
