Athletic Club will be boosted by the return of midfielder Ruiz de Galarreta, who is available again after serving a suspension. However, Oihan Sancet remains banned for the Basque outfit.
The Lions continue to grapple with a lengthy injury list, with Benat Prados, Unai Egiluz, Maroan Sannadi and Robert Navarro all ruled out. Inaki Williams has missed the last seven matches due to a groin issue and remains a major doubt for Wednesday’s clash.
Navarro’s absence could pave the way for Unai Gómez to step into the starting XI, while promising 18-year-old Selton Sánchez is also in contention for a start. Aymeric Laporte is expected to return after missing the Levante encounter through illness.
Real Madrid, meanwhile, are still without Dani Carvajal, who continues to recover from a knee injury. Dean Huijsen, David Alaba and Raul Asencio will all require late fitness checks ahead of the match.
However, the Spanish champions were encouraged by the return of Éder Militão and Antonio Rüdiger in the win over Girona, and the centre-back pairing is likely to be retained. Álvaro Carreras should also reclaim the left-back position.
In midfield, Eduardo Camavinga could be restored to the lineup in place of Arda Güler, while Jude Bellingham may operate just behind a front duo of Vinícius Júnior and Kylian Mbappé.
